Cell Biology and Molecular studies for MD-PhD Student

July 19, 2008
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The project will have a significant impact on the field of neuroprotection both at the basic and applicative levels. We expect to gain fundamental knowledge on neuroprotection mechanisms from the molecular up to organ levels. P2Y-receptors have been scarcely studied as targets for neuroprotection. Nucleotide analogues have not been studied before as biocompatible antioxidants. In addition, our concept of dual-action neuroprotective substances is unique.
We search for blood-brain-barrier (BBB)-permeable neuroprotective agents that are both antioxidants and P2Y-Rreceptor agonists. These agents are based on metabolically stable nucleotide analogues, for some of which we have already demonstrated both high antioxidant activity.
The Project has cell biologic and molecular spectrum of methods.
The project is for PhD or MD students.

References:
Hein, S., Schönfeld, P., Kahlert, S. and Reiser, G. Toxic effects of X-linked adrenoleukodystrophy-associated, very long chain fatty acids on glial cells and neurons from rat hippocampus in culture. Human Mol. Genetics 17 (2008) 1750-1761.

Wang, Y., Luo, W. and Reiser, G. Activation of protease-activated receptors in astrocytes evokes a novel neuroprotective pathway through release of chemokines of the growth-regulated oncogene/cytokine-induced neutrophil chemoattractant family. Eur. J. Neurosci. 26 (2007) 3159-3168.

Contact:

Prof. Dr. Georg Reiser
georg.reiser@med.ovgu.de
Otto-von-Guericke Universität – Institut für Neurobiochemie
Magdeburg

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