Dissertation/Thesis Project: protein engineering of protein Tumorigenic Targeting Peptides
Dissertation / thesis: protein engineering of protein Tumorigenic Targeting Peptides: Most human cancers are characterized by deregulated expression of certain proteins or generation of unnatural fusion proteins through chromosomal translocation. Our aim is to generate peptides that effectively block these cancerous proteins and to restore the “normal” state of the cell. Current targets include c-Jun, c-Fos, c-Myc, AF10 and AML1-ETO.
Methoden:
We use a combination of rational design as well as evolutionary approaches combined with in vivo and in vitro selection systems to generate peptides specific for their target proteins. Our lab uses a broad spectrum of methods: molecular biology, selection techniques, rational design, protein biochemistry, biophysical analyses, cell biology, informatics and proteomics. Experience on one or more areas is desired.
Anfangsdatum: 15. November 2008
geschätzte Dauer: 3 Jahre
Bezahlung: TV-L E 15 (50%)
Veröffentlichungen:
Jouaux, E.M., Schmidtkunz, K., Müller, K.M. & Arndt, K.M. (2008). Targeting the c-Myc coiled coil with interfering peptides to inhibit DNA binding. J. Pept. Sci. 14 (9), 1022-1031.
Hagemann, U.B., Mason, J.M., Müller, K.M. & Arndt, K.M. Selectional and mutational scope of peptides sequestering the c-Fos coiled coil domain. J. Mol. Biol. 381 (1), 73-88.
Mason, J.M., Müller, K.M. & Arndt, K.M. (2007) Positive Aspects of Negative Design: Simultaneous Selection of Specificity and Interaction Stability. Biochemistry 46, 4804-4814
Mason, J.M., Schmitz, M.A., Müller, K.M. & Arndt, K.M. (2006) Semirational design of Jun-Fos coiled coils with increased affinity: Universal implications for leucine zipper prediction and design. Proc. Natl. Acad. Sci. USA 103(24), 8989-8994.
Mason, J.M. & Arndt, K.M. (2004). Coiled coil domains: stability, specificity, and biological implications. ChemBiochem 5(2); 170-6.
Homepage: http://www.molbiotech.uni-freiburg.de/ka/
The position is funded by the German Excellence Initiative in the School of Life Science of the Freiburg Institute for Advanced Studies (FRIAS – LIFENET). The lab is embedded in an environment with state-of-the-art equipment and facilities (genomics, proteomics, life imageing) for systems biology as well as synthetic biology approaches.
Scholarship Tags: Dissertation, Engineering, Peptides, Project, Protein, Targeting, Thesis, Tumorigenic
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