DOCTORAL RESEARCH FELLOW POSITION University of Oslo

October 2, 2007

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DOCTORAL RESEARCH FELLOW POSITION (PhD-stipendiat) is available at the DEPARTMENT OF MOLECULAR BIOSCIENCES, Faculty of Mathematics and Natural Sciences, University of Oslo
The position is available for a period of three years
Project start date: as soon as possible
The position is associated to the research project Epigenetic gene regulation: The ‘conspiracy’ between chromatin modification and transcription factors funded by the Functional Genomics Programme (FUGE) of the Research Council of Norway.
The organization of DNA into higher order chromatin structure is crucial for the correct temporal and spatial regulation of gene expression. Post-translational modifications of the histones influence chromatin structure (cfr. the histone code). The aim of this project is to shed light on the role of methylation of histone tails, which is conducted by SET-domain proteins that act as histone methyltransferases in epigenetic regulation of differential gene expression. The project will provide insight in the biochemical and biological function of selected SET-domain proteins, and more specifically link these proteins to target genes that they regulate, either on their own, via DNA methylation, or via protein complexes, including complexes with transcription factors. Arabidopsis thaliana, a plant with exquisite tools for functional genomics and epigenomics, will be used as model organism.
The project is a collaboration between Prof. Reidunn B. Aalen at the Department of Molecular Biosciences, University of Oslo (http://www.imbv.uio.no/gen/db03-ansatte/internet/html/nr000070.html) and Prof. Rein Aasland at the Department of Molecular Biology, University of Bergen (http://www.uib.no/mbi/research/aasland.html). Two post.doc.s, another PhD student and Masters students will be involved in different aspects of this project (biochemistry, molecular genetics, bioinformatics, and structural biology) in addition to the PhD-student of the announced position. We collaborate with several research laboratories in Europe, and the offered the PhD positioned is expected to have research stays in collaborating labs.
The position requires a Master degree or similar within molecular biology, cell biology, biotechnology, or biochemistry. The applicant must be qualified for the doctoral program within these disciplines. Experience with expression of recombinant proteins, protein-protein interactions, methods relevant for investigations of chromatin and or Arabidopsis research, is an advantage, but not a requirement.
The letter of application should include a curriculum vitae with a list of published and unpublished works with a statement summarizing the applicant’s scientific work and interests, certified copies of certificates, and copies of co-authored publications.

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