PhD GRAD. STUDENT POSITION IN CANCER RESEARCH IN BERLIN AVAILABLE (Berlin)

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February 1, 2008

in the lab of Prof. Clemens Schmitt working on

Genetic Mechanisms of Drug-Induced Senescence in vivo

We are interested in genetic programs and mutations which impact on tumor development and sensitivity to anticancer therapies. Utilizing a transgenic mouse model, we generate primary lymphomas with defined genetic lesions by intercrossing to knockout mice and by retroviral gene transfer into established lymphoma cells or hematopoietic stem cells. These tumors are transplantable and undergo anticancer treatment at their natural sites. Using this tractable system, which recapitulates typical features of human Non-Hodgkin’s lymphomas, we study genetic and biochemical effects of oncogenic action and drug responses in vivo. We are particularly interested in the contribution of cell-autonomous and environmental defects in drug-induced apoptosis and premature senescence to chemoresistance. Our aims are to elucidate molecular mechanisms of cellular senescence and drug resistance in order to develop novel targeted therapies. For information in greater detail please see for example Sc!
hmitt-CA et al., Genes Dev. (1999), 2670, Schmitt-CA et al., Nature Med. (2000), 1029, Schmitt-CA et al., Cancer Cell (2002), 289, Schmitt-CA et al., Cell (2002), 335, Braig-M et al., Nature (2005), 660, and Bouchard-C et al., Genes Dev. (2007), 2775; furthermore, see Schmitt-CA, Biochimica et Biophysica Acta (2007), 5, for an overview. This study group is embedded in a combined clinical and basic research campus, since its group leader is affiliated with both the Department of Hematology-Oncology at Charité-Virchow Campus (Humboldt-University) and the distinguished Max-Delbrück-Center for Molecular Medicine in Berlin. Berlin is the scientific place to work, provides a very international environment and high life quality, and is one of the most beautiful cities in Europe.

REQUIREMENTS

Join our highly-motivated team if you are interested in creative approaches and non-conventional strategies to dissect the pathways of chemoresistance in vivo. You are eligible for a German Ph.D., and you are familiar with basic techniques in molecular biology, biochemistry and handling of (primary) cells (for example cloning, analyses of proteins and DNA/RNA, cell culture, immunohistochemistry, or flow cytometry). Lab communication is in English. Please send your CV including a list of publications and your strongest technical skills with two references/letters of recommendation to

Prof. Dr. Clemens A. Schmitt, M.D.
Max-Delbrück-Center for Molecular Medicine and
Charité/Campus Virchow/Hematology-Oncology
Augustenburger Platz 1
D-13353 Berlin
Germany
e-mail clemens.schmitt@charite.de

Scholarship Tags: available, Berlin, CANCER RESEARCH, GRAD, PhD, STUDENT POSITION