PhD Position of Leukemia Research Group Zurich, Switzerland
Job Description:Acute lymphoblastic leukemia (ALL) is the most common malignancy in childhood. ALL relapse remains one of the most frequent diagnoses in pediatric oncology. These patients desperately need new treatment options. Combination therapy with new agents that target regulators of programmed cell death constitutes a promising approach to improve treatment of resistant disease. Our own data support the potential of the pan-BCL-2 antagonist obatoclax as chemosensitizer in drug resistant ALL (Bonapace et al., Journal of Clinical Investigation, 120, 1310-23). Subcytotoxic concentrations of obatoclax very effectively resensitized cells from treatment refractory ALL patients to glucocorticoids. Unexpectedly, combination of obatoclax with dexamethasone triggered an alternative non-apoptotic but necroptotic cell death pathway. This alternative cell death pathway was dependent of induction of autophagy. Based on these data, we are now planning a phase I/II trial together with the!
resistant disease committee of the BFM study group and the European Consortium ‘’Innovative Treatment for Childhood Cancer’’ (ITCC) to test obatoclax in combination with dexamethasone for refractory ALL.
Thesis Project: In this PhD thesis project, we propose to explore the mechanisms that underlie the chemosensitzation activity of small molecules such as obatoclax in drug resistant disease. In particular the crosstalk between autophagy, apoptosis and necroptosis will be investigated. Preliminary genetic data suggest an unexpected link to the death receptor complex that warrants intensive investigation. In order to facilitate the planned clinical trial with obatoclax, we also aim at establishing molecular markers as well as predictive markers of response.
Application Deadline 1 July 2010
Scholarship Tags: crosstalk, Leukemia, research, Switzerland, Zurich
Scholarship Search
Important: Scholarship-Positions.com is not responsible for the content of any external websites linked to or referenced on this site.
Browse Scholarships
- Africa Scholarships
- Australia Scholarships
- Austria Scholarships
- Belgium Scholarships
- Canada Scholarships
- China Scholarships
- Denmark Scholarships
- France Scholarships
Recent USA Scholarships
2012 The Charles Braver Language Exploration Grant at Russia, Kyrgyzstan, or Ukraine 2012 Development Fund for Black Students in Science and Technology, USA Boren Fellowships for U.S. Graduate to Study Abroad, 2013/14 2012 Jackson Hole Science Media International Awards, USA 2012 POMEPS TRE Grants in Political Science, USARecent UK Scholarships
RGU: Sport Scholarship at Robert Gordon University, UK 2012 Transform Together Scholarships for International Students, UK 2012 Sarmatian Bursary for Undergraduate at University College London, UK 2012 Architecture,Construction and Surveying Merit Scholarships at Robert Gordon University, UK 2012/13 2012 North American Merit Postgraduate Scholarship at Queen’s University Belfast, UKRecent Germany Scholarships
2012 PhD Thesis Position in Geomicrobiology at University of Tübingen, Germany PhD Position in Model Systems of Infectious Diseases at Leibniz Center Infection (LCI), 2012 Germany PhD Student in Quantitative Disease Proteomics at University of Freiburg, 2012 Germany PhD Studentship in Isotope Biogeochemistry at Helmholtz Centre for Environmental Research GmbH – UFZ, 2012 Germany 2012 PhD Position in System Ecotoxicology at Helmholtz Centre for Environmental Research – UFZ, GermanyRecent India Scholarships
3 PhD Position at PSG Institute of Advanced Studies, India 2012-2013 Trio World School Scholarships for High School Students, India 2012-2013 Meena Srinivasan Memorial Awards for Indian Artists, India 2012 Indo-Korean Joint Programme of Cooperation in Science and Technology, India 2012 Queen’s University Management School Postgraduate Scholarships for Indian Students, UKWomen Scholarships
UNESCO-L’OREAL International Fellowships Programme for Women in Life Sciences, 2013 Dulcie Bowman Scholarship for Hearing Impaired Women Students, New Zealand 2012 2013 Barbara Wood Memorial Foundation Scholarship, New Zealand and South Pacific The Eira Francis Davies Scholarship at Swansea University, 2012 UK Conchita Poncini Jimenez International Human Rights Fellowship at IFUW, 2012-2013Africa Scholarships
2012 TBA Masters Scholarship for African Citizens, Africa The Tropical Biology Association Small Grant, 2012 Africa 2012 Cranfield University MBA Scholarships, UK Postdoctoral Fellowship in Social Science at CODESRIA, 2012 Africa 2013 Research Partnership Ivorian-Switzerland Scholarship, AfricaScholarship Blog
Useful Links
Search in Worldwide UniversitiesOxford Laboratory Technology
Search Courses in Indian Universities
IndiaJobs.co.in, India Jobs Employment, Recruitment, Careers, Interview
Teaching, Professor Jobs in India
GRE Prep and Free Courses