PhD Position: Role of the membrane-bound bile acid receptor TGR5 in the liver
September 16, 2008
PhD-Position in the Sonderforschungsberich 575 Experimentelle Hepatologie (Gebäude 13.54, Ebene 00, Raum 92/ Moorenstraße 5, 40225 Düsseldorf
The project A10 entitled „Role of the membrane-bound bile acid receptor TGR5 in the liver” is looking for a highly motivated PhD student. The projects investigates the function of the novel, G-protein coupled bile acid receptor TGR5 in the liver. Bile acids are not only essential for dietary lipid absorption and cholesterol excretion, but are signalling molecules with endocrine functions. Bile acids can activate intracellular signalling pathways and modulate gene transcription through nuclear bile acid receptors. TGR5 is a G-protein coupled, plasma membrane bound bile acid receptor, which is expressed in many human and rodent tissues, including different non- parenchymal cells of the liver (Keitel et al. Hepatology 2007, Keitel et al., BBRC 2008). Aim of the project is to elucidate the expression, localization and function of the membrane bound bile acid receptor in the liver. TGR5 activated signalling pathways will be investigated in isolated liver cells and transfected cell lines. Using TGR5 knockout mice the function of the receptor will be studied in different models of cholestatic liver disease.
Methods: Standard techniques of molecular cell biology (e.g. cloning of cDNA, insertion of mutations using site-directed mutagenesis, quantitative realtime PCR), cell culture techniques and transfection, immunofluorescence staining and confocal laser scanning microscopy, live cell imaging FRET and TIRF microscopy to study protein-protein interactions and trafficking of the receptor. Isolation of different cell types from rat and mouse liver and animal experiments.
We offer close supervision in an interdisciplinary team and stimulating environment as well as participation in our “Graduiertenkolleg” with seminars and practical courses.
Further information can be obtained under: www.uni-duesseldorf.de/sfb575
Applications should be addressed to: Dr. med. Verena Keitel, Klinik für Gastroenterologie, Hepatologie und Infektiologie (Direktor: Prof. Dr. D. Häussinger), Moorenstrasse 5, 40225 Düsseldorf; Verena_Keitel@gmx.de
Tags: Biology, Cell Biology, FRET, germany, PhD, Position, Proteins
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Posted by Scholarship Position Team | Scholarship Category Germany PhDs
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I have done my MSc and BSc in Statistics at Addis Ababa University, and currently teaching at Hawassa University, Ethiopia. Would you, please, facilitate me a scholarship opportunity so that I can do my PhD there in Germany?
Thank you in advance.
Yours sincerely,
i have completed my M.Sc in Human physiology from nepal B.P koirala institute of health science and now working as a lecturer in china three gorges university ,could u please provide me oppurtunity to do phd in there.
Dear Sir/ Madam,
It gives me pleasure to make correspondence concerning
my further study. I have already completed my M. Sc.
degree in Biochemistry from Central
Department of Chemistry, Tribhuvan University, Nepal.
These days I have been involving in Advanced College of Engineering And Management in the Capacity of Assistant professor and researcher.
Now, I am solely interested to achieve my furthers
degree in Role of the membrane-bound bile acid receptor TGR5 in the liver from your esteemed university.
In this connection, I would like to request you to
kindly consider my candidature as a doctoral student
at your University.
So far about my academic background is concerned, As mentioned above I am an M. Sc. graduate in chemistry
and a author of text book of Chemistry for Enginers for Engineers Provided the opportunity, I would
like to assure you that I can accommodate myself to
the ongoing research programme of yours. I am looking
forward to your responses.
With respectful regards
Sincerely Yours
Lekhnath Ghimire
i am an M.Ed graduate from Haramaya university ,Ethiopia. With a cummulative GPa of 4.00. in october 2008 . I did a thesis research entitled with evaluation of implementation of biology curriculum in Dessie college of Teachers’ education. the work was recommended as it was very good by the department head of biology and dean faculty of haramaya university. i have a great interest to join PhD program in one of the subdesciplines of biology .Reference :Ameha Kebede,Department head,haramaya university, ethiopia.cellophone:251911834681 office;251255530380so if you have a space contact me with this e-mail: dressabbebawabayneh@yahoo.com
Dear Sir/madam: i m a master in biotechnology from university of the punjab lahore, pakistan. i liked the project for my Ph.D research and i would like your supervision for that task. i would be thankful to you if you provide me a chance. i assure you that you will find me a hardworking person.
iam salma from sudan ,gezira university ,physiology
please help me to find phd programe