PhD Positions and Postdoc Fellowships, Heidelberg, Germany

September 5, 2008

PhD Positions and Postdoc fellowships (Heidelberg, Germany): We are interested how cytoskeletal dynamics control cell invasion and transcription. In particular we study regulatory interactions with the actin assemblying Diaphanous Formins to dissect their specific functions and physiological roles in various cell motility processes such as cancer cell invasion and polarized cell movement. Additionally, most Formins govern transcriptional activities through their effects on actin dynamics. We would like to understand the synergistic link between Formin-induced cytoskeletal dynamics and transcriptional output important for cancer cell invasion and metastasis.

Further reading:
Fackler O.T., Grosse R. (2008) Cell motility through plasma membrane blebbing.J. Cell Biol. 181:879-884

Goulimari P., Knieling H., Engel U., Grosse R. (2008) LARG and mDia1 link G12/13 to cell polarity and microtubule dynamics. Mol. Biol. Cell 19:30-40

Kitzing T.M., Sahadevan A.S., Brandt D.T., Knieling H., Hannemann S., Fackler O.T., Großhans J., Grosse R. (2007) Positive feedback between Dia1, LARG and RhoA regulates cell morphology and invasion.
Genes Dev. 21:1478-1483

Brandt D.T., Marion S., Griffiths G., Watanabe T., Kaibuchi K., Grosse R. (2007) Dia1 and IQGAP1 interact in cell migration and phagocytic cup formation. J. Cell Biol. 178:193-200

Faix J., Grosse R. (2006) Staying in shape with formins.
Dev. Cell 10:693-706

Grosse R., Copeland J.W., Newsome T., Way M., Treisman R. (2003). A role for VASP in Rho-diaphanous signalling to actin dynamics and SRF activity.EMBO J. 22:3050-3061

We will preferentially consider strong applications from candidates eligible for on and off campus fellowships.

TO APPLY, please contact:


Dr. Robert Grosse
Emmy Noether Research Group
Institute of Pharmacology
Medical Faculty, University of Heidelberg
Im Neuenheimer Feld 366
69120 Heidelberg, Germany

Tel: +49 6221 54 8619 / 8646
Fax: +49 6221 54 8549
robert.grosse[at]pharma.uni-heidelberg.de
Web:http://www.pharmakologie.uni-hd.de
member of www.cellnetworks.uni-hd.de
and The Invadosome Consortium

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