PhD Program University of Lausanne Switzerland
A PhD position is available in the Department of Medical Genetics (DMG)
in the laboratory of Dr. Roman Chrast. The proposed project will take
advantage of different transgenic mouse models available in the lab to use
a combination of functional genomics, developmental neurobiology and
molecular biology to study establishment and progression of peripheral
neuropathy in its inherited forms (Charcot-Marie-Tooth disease) and forms
associated with diabetes mellitus (Diabetic neuropathy). We are especially
interested in the mechanism of interactions between axons and glial cells
and how these interactions are disturbed in the case of neuropathy.
The DMG is part of the Faculty of Biology and Medicine of the University
of Lausanne. It offers an excellent multidisciplinary environment, occupies
state of the art research laboratories and benefits from the access to
university core facilities (including genomics, proteomics, transgenic
animal facility, cellular imaging and bioinformatics). In addition to its close
collaboration with the other departments at the university, the DMG
benefits from its participation in the « Lausanne-Geneva research network
» also including the University of Geneva and the Swiss Federal Institute
of Technology (EPFL) in Lausanne.
For more info please check: http://www.unil.ch/dgm/page18811_en.html
Representative publications:
1.) Nadra, K, de Preux Charles, A.S., Medard, J.J., Hendriks, W.T., Han,
G.S., Gres, S., Carman, G.M., Saulnier-Blache, J.S., Verheijen, M.H.,
Chrast, R. (2008) Phosphatidic acid mediates demyelination in Lpin1
mutant mice. Genes & Dev. 22: 1647-61.
2.) de Preux, AS., Goosen, K., Zhang, W., Sima, AAF., Shimano, H.,
Ouwens, MD., Diamant, M., Hillebrands J., Rozing, J., Lemke, G.,
Beckmann JS., Smit AB., Verheijen, MHG., and Chrast, R. (2007)
SREBP-1c expression in Schwann cells is affected by diabetes and
nutritional status. Mol Cell Neurosci. 35: 525-34.
3.) Verheijen MH, Chrast R, Burrola P, Lemke G. (2003) Local regulation
of fat metabolism in peripheral nerves. Genes & Dev. 17:2450-64.
A successful candidate joining the lab for a PhD thesis will be expected to
participate in the graduate program in neuroscience. This program is
organized by the University of Lausanne, University of Geneva and EPFL
and it offers an excellent choice of practical and theoretical courses
covering topics ranging from neurogenetics to behavioral neuroscience
including molecular, cellular, cognitive, and computational neuroscience.
More information about the PhD program can be found here:
http://www.lemanic-neuroscience.ch/phd/
http://www.unil.ch/fbm/page17130_en.html
Scholarship Tags: PhD, Program, Switzerland, University of Lausanne
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