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June 3, 2007

The research group of Dr. Gert Jansen is situated in the Department of Cell Biology, headed by Prof. Dr. Frank Grosveld, of the Erasmus MC, Rotterdam. The Department has a modern infrastructure that is shared with a number of other Departments in the faculty (Genetics, Biochemistry, Reproduction and Development, Forensic Molecular Biology, Bio-informatics and Clinical Genetics). The Department has an international PhD program (approximately 30 students from many different countries).
The regulation of intraflagellar transport in the cilia of mammalian kidney cells. In the kidney, cilia monitor fluid flow and regulate cell proliferation and differentiation. Disruption of cilia function
can cause polycystic kidney disease. The development and function of cilia require transport structural components and signalling molecules along the cilia, mediated by intraflagellar transport (IFT). Recent results
suggest that IFT is regulated, allowing modulation of cilia length and organization of signalling pathways in cilia. We recently identified a conserved MAP kinase, DYF-5, which is involved in the regulation of IFT in the nematode
C. elegans (Burghoorn et al. 2007, PNAS 104, 7157). Mammals have three DYF-5 homologues. We expect that at least one of these has a similar function in the regulation of IFT. The PhD student will study the regulation of IFT in mammalian kidney cells using life imaging of IFT and knockdown and overexpression of the mammalian homologues of genes that play a role in this process in C. elegans.
Requirements:
We are looking for an enthusiastic and motivated young scientist who has recently completed his/her MSc (doctoraal) in Biology or a similar discipline. The candidate should preferably have some knowledge of and experience with imaging and molecular biological techniques. The department of Cell Biology is internationally
orientated, so English language skills are essential.
We offer you an appointment as a PhD student for a period of 4 years. You are an employee of the Erasmus MC (Nierstichting, Dutch Kidney Foundation grant). The gross monthly salary amounts to ? 1937 in the 1st year and
increases to ? 2482 in the 4th year with a full-time appointment, according to the PhD salary scales of the CAO UMC. The conditions of employment are in accordance with the Collective Bargaining Agreement for University
Medical Centres (CAO UMC).
For more information about this position, please contact Dr. G. Jansen by e-mail g.jansen@erasmusmc.nl. For other information, please contact John van der Voort, HRM Consultant, tel. + 31 10 – 4638037, or by e-mail to j.vandervoort@erasmusmc.nl.
Please send your application with CV by e-mail to g.jansen@erasmusmc.nl, or to Erasmus MC, Department of Cell Biology, Dr. G. Jansen, P.O. Box 2040, 3000 CA Rotterdam, The Netherlands, stating vacancy number 21.09.07.C15 on both the letter and the envelope.