PhD Student Position in Nanotoxicology for Studies of Skin Exposure of Nanoparticles,Sweden
Job Description: he skin is our largest organ. It is a very important defence against dehydration and external threats such as radiation, chemicals and microorganisms. Many factors determine the degree of penetration of chemical substances and particles through the skin, such as size, reactivity and surface properties. The question regarding nanoparticles ability to penetrate into or through the skin has been debated. This debate is driven by the fact that several everyday products, such as sunscreens and cosmetics, contain large quantities of nanoparticles. Many of these particles, e.g., TiO2are non-bioresorbable and might cause undesired toxicological effects if penetrating into the skin. A few studies exist where nanoparticle skin penetration has been observed. Thus, there is a need for more investigations in order to link specific particle properties, such as size and hydrophobicity, with skin penetration abilities.
The objective of the PhD-project is to link the properties of nanoparticles to their skin penetration abilities. This will include synthetisation and characterisation of nanoparticles with different properties in a controlled manner. Skin penetration will be assessed by performing skin permeation experiments using excised donated human skin and combining with various imaging techniques, e.g. electron microscopy and multiphoton laser scanning microscopy. The project will be executed within the NanoSphere centre, which is devoted for nanotoxociology risk studies and is funded by FORMAS, and the Centre for Skin Research at University of Gothenburg. These two centres provides access to necessary competence and instrumentation for the project.
Required qualifications
The position suits a highly motivated individual with a well-documented solid background in Chemistry, Materials Science, or related fields. Previous experience with synthesis of nanoparticles using surfactant self-assembly and experience from working with TEM and X-ray diffraction is required.
The candidate is expected to have good presentation skills and speak English fluently. Masters Degree (or equivalent) in Chemical engineering, Chemistry or other related disciplines is required.
Application procedure
The application shall be written in English and include the following items:
1. An application of a maximum of one A4 page containing your specific qualifications for the position
2. Attested copies of education certificates, including grade reports and other documents
3. Curriculum Vitae
4. Letters of recommendation and name of reference persons (optional)
Application Deadline 26-July2010
Scholarship Tags: exposure, nanoparticles, Science, Skin, Sweden, Technology
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