Phd Studentship in Novel Scents and Drugs through an Expansion of the Terpenome, UK
PhD Studentship,Novel Scents and Drugs through an Expansion of the Terpenome,Cardiff University,UK
Job Description: The recent resurgence of natural products chemistry has been driven by the need for new compounds with useful applications and by new basic work that has led to an understanding of how the chemical diversity observed in bioproducts such as polyketides is generated. Only recently have the details begun to emerge of how the remarkable diversity in the terpenome is created by Nature. One of the key steps is the conversion of the linear precursors of all terpenes into (mostly) cyclic hydrocarbon products by the family of closely related terpene synthases. Recent work has revealed many of the intricate mechanistic details of sesquiterpene synthase chemistry, and has indicated that a simple combinatorial code exists within a shared protein fold that determines the catalytic outcome of terpene synthase catalysed reactions. Hence terpene synthase chemistry is a classic example of combinatorial chemistry. While biosynthetic constraints limit the substrate pool of terpene synthases in nature to only a small number of isoprenyl diphosphates, it has become apparent that it is possible to expand the vast pool of naturally occurring terpenoids (the terpenome) through the enzymatic conversion of non-natural substrate analogues. This provides an approach for the generation of terpenoids and terpenoid analogues, molecules that have historically been difficult to obtain synthetically because of their highly complex molecular architectures.
We are seeking a bright and highly motivated student to join a dynamic, multidisciplinary research group in Chemical Biology to work on a project that combines synthetic organic chemistry, chemical biology and mechanistic enzymology to elucidate the enzymatic reaction mechanisms of terpene biosynthesis and to generate novel “non-natural” natural products with biological and medicinal activities.
Application Deadline 31August 2010
Scholarship Tags: Expansion, PhD, Scholarship, Technology, Terpenome, UK, University
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