PhD Studentship in Systems Biology, UK

July 28, 2010
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PhD Scholarship in System Biology in the department of in the School of Veterinary Sciences at the University of Liverpool, UK
Job Description: A four year (1+3) BBSRC Doctoral Training Grant (DTG) PhD studentship. Training in the application of Systems Approaches to Biological Research. Students will participate in taught courses and research projects in Year 1 (MRes in Post-Genomic Science) and follow a three year PhD training programme in Years 2-4. The University has outstanding cross-departmental enabling technologies including Advanced Genomics and Microarray Facilities, Functional Proteomics laboratories and Bioinformatics expertise. The opportunity to develop skills in Systems Biology, that bridge the gap between experimental and theoretical knowledge, will provide excellent career prospects for the successful applicant.

The PhD project will focus on the optimisation of mesenchymal stem cell culture systems to produce in vitro tissue-replicas for therapeutic use. Three-dimensional cell culture systems are used as drug screening systems, as in vitro models of intact tissue, and in tissue engineering. This project will compare 2D and 3D culture systems with intact tissues of mesenchymal origin. Transcriptomics and bioinformatics will be used to discover specific regulators of three-dimensional tissue function. Data evaluation and rationalisation will be used to make directed iterative improvements to the engineered culture systems and produce engineered skeletal tissues of practical use in research and medicine.

This studentship is funded by the BBSRC for UK or for EU citizens who will have been resident in the UK for at least three years. Candidates should hold a First or Upper Second class Honours degree in a relevant Biological subject, or in Computer Science/Mathematical Sciences if accompanied by experience in the Life Sciences. Applicants who already hold a Masters degree in a relevant discipline will not have a formal requirement to complete the MRes year, but will take modules as required to gain additional skills in key areas.

Contact Dr Elizabeth Laird (0151 794 6026, Elizabeth.Laird@liverpool.ac.uk), or Professor Peter Clegg (0151 794 6077/6041, p.d.clegg@liv.ac.uk), for further information, or for details on how to apply.

Closing date for receipt of applications: 15 August 2010

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