Postdoc Position in the study of genetic conflicts in cancer, University of East Anglia – UK

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February 25, 2009

Project title: Genetic conflicts in cancer: from evolutionary principles to
mechanisms underlying increased cancer risk

SCHOOL OF BIOLOGICAL SCIENCES, UNIVERSITY OF EAST ANGLIA, NORWICH, UK

1 year POST-DOCTORAL RESEARCH ASSOCIATE POSITION

Salary: From GBP 29,704 per annum

A full time postdoctoral position, funded by the BigC Local Cancer Care
(http://www.thebigcappeal.co.uk/), is available for 12 months in the
laboratory of Dr Tracey Chapman and Professor Dylan Edwards (see
http://www1.uea.ac.uk/cm/home/schools/sci/bio/people/Faculty) in the School
of Biological Sciences and Biomedical Research Centre at UEA.

An immediate start date is available and the position must be filled as soon
as possible.

Synposis: There is great value in applying principles of evolutionary
biology to the study of cancer. It can explain the high prevalence of cancer
in humans and why cancer genes are often positively favoured by selection.
For example, genes with beneficial effects early in life can be strongly
favoured, even if the cost in later life is cancer. Conflicts of interest,
for example between males and females, may also be an important source for
increased cancer risk. We have recently shown that the experimental
application of increased mating stress results in disregulation in
reproductive hormone signalling and microRNA biosynthesis genes. These
changes were associated with significantly increased death rate and are
potentially significant in the context of cancer. In this proposal we aim to
build upon this work, to understand (i) whether microRNAs themselves are
differentially expressed in response to mating conflict and (ii) the
mechanistic basis of how changes in gene expression (and gene translation
controlled by microRNAs) leads to loss of organismal integrity and increased
death rate. The research is important because of the need to understand the
fundamental principles of how evolution acts on genes that increase cancer
risk.

More information about the School of Biological Sciences can be found at

http://www.uea.ac.uk/bio/

Informal enquiries to Tracey Chapman (tracey.chapman@uea.ac.uk)

Closing date: 6th March 2009.
Interview date: Week beginning March 16th 2009

Applications via:

http://www.uea.ac.uk/hr/jobs/ra/ra553.htm

Please send a CV and cover letter in addition to the application form.

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