Postdoctoral Position in Biochemistry and Biophysics USA
Postdoctoral Position in Biochemistry and Biophysics (Galveston/USA)The hallmark of cancer biology is the uncontrolled growth of cells. This transformation relies on mutant cell signaling proteins such as Src, Raf-1, Erb, Her2, Bcr-Abl and others that are constitutively active and/or hyperactive leading to uncontrolled proliferation. In contrast to their normal counterparts, the activity of these mutant oncogenic proteins is highly dependent upon interaction with the molecular chaperone Hsp90. In normal cells, Hsp90 oversees the folding of client proteins. In cancer cells, Hsp90′s essential role is subverted to stabilize mutated oncogenic proteins resulting in neoplastic transformation. Hsp90 binds and hydrolyses ATP, an activity that is inhibited by the ansamycin antibiotic geldanamycin. Geldanamycin binds to the nucleotide binding pocket of Hsp90, displaces ATP and inhibits activation of numerous Hsp90 dependent oncogenic clients, making it an ideal candidate for broad spectrum cancer treatment. This project funded by TI-3D (Texas Initiati!
ve for Drug Discovery and Development) will focus on the characterization of newly designed synthetic derivatives of Geldanamycin, analyze their interaction with Hsp90 and test their potency to inhibit the Hsp90 dependent activation of oncogenes. For further information see our website: www.utmb.edu/ncb/Faculty/ObermannWolfgang.html
Requirements
The successful candidate will an expert in the generation of recombinant proteins and must be experienced in the analysis of protein-drug interactions by biophysical methods such as SPR (surface plasmon resonance) spectroscopy, fluorescence spectroscopy and ITC (isothermal calorimetry).
Please forward your application letter stating clearly how you pertain to the requirements for the position together with a curriculum vitae, a list of publications, and the names and contact information of three referees to wmoberma@utmb.edu
Contact:
Wolfgang M. J. Obermann, PhD, Associate Professor
Department of Neuroscience and Cell Biology
The University of Texas Medical Branch
Research Building 17, Rm. 5.212A
Galveston, TX 77555-0620
USA
Phone: ++1-409-747-1214
Email: wmoberma@utmb.edu
Scholarship Tags: Biochemistry, Biophysics, Position, Postdoctoral, USA
Scholarship Search
Important: Scholarship-Positions.com is not responsible for the content of any external websites linked to or referenced on this site.
Browse Scholarships
- Africa Scholarships
- Australia Scholarships
- Austria Scholarships
- Belgium Scholarships
- Canada Scholarships
- China Scholarships
- Denmark Scholarships
- France Scholarships
Recent USA Scholarships
The AIA Society Outreach Grant Program at Archaeological Institute of America, 2012 USA The Archaeology of Portugal Fellowship for International Students at AIA, 2012 USA 2013 Teaching Excellence and Achievement Program, USA International Leaders in Education Program for Indian Teachers, 2013 USA 2012-2013 Kathern F. Gruber Scholarship and Thomas H. Miller Awards, USARecent UK Scholarships
Kingston University Undergraduate International Scholarships, 2012 UK Overseas Research Scholarship (ORS) for Non-EU Applicants at University of York, 2012 UK Scholarship for Overseas Students (SOS) at University of York, 2012 UK Kingston University International Postgraduate Scholarships, 2012 UK 2012 Donner Scholarship at University of Cambridge, UKRecent Germany Scholarships
CGS Interantional Scholarships for Doctoral Program at University of Cologne, 2012 Germany Max F. Perutz International PhD Programme in Chromosome Dynamics, 2012 Germany PhD Positions in NanoBioTechnology at Center for NanoScience LMU, 2012 Germany PhD in Life Sciences at The International Giessen Graduate School for the Life Sciences, Germany Germany Postgraduate Training Program – 2012 Cycle (PhD studies in Germany)Recent India Scholarships
Kingston University Postgraduate Scholarships for Indian Students, 2012 UK 2013 Teaching Excellence and Achievement Program, USA Fulbright Foreign Language Teaching Assistant Program for Indian, 2013 USA 2013 Fulbright-Nehru Senior Research Fellowships for Indians, USA 2013-2014 Fulbright Teacher Exchange Program for US and Indian Students, USA and IndiaWomen Scholarships
Sloan MSc Women’s Scholarship at London Business School, 2013 UK 2012-2013The Saint Paul College Club, Inc. AAUW Undergraduate Scholarship, USA 2012 L’Oréal Canada for Women in Science Research Excellence Fellowships, Canada 2012 Gertrude M. Cox Scholarship at American Statistical Association to Study in USA, Canada 2012 Women in Games Scholarship at Vancouver Film School, CanadaAfrica Scholarships
2012-2013 South Africa Investec Scholarship for MBA Students, UK 2012-2013 Mandela Magdalene College Scholarship for South Africa, UK 2012 Call for Proposals: Grant Awards for Global Environmental Change Research, Africa CARTA Call for Applications for PhD Fellowships 2012-2013, Africa Africa Biosciences Challenge Fund Research Fellowship, 2012 AfricaScholarship Blog
Useful Links
Search in Worldwide UniversitiesOxford Laboratory Technology
Search Courses in Indian Universities
IndiaJobs.co.in, India Jobs Employment, Recruitment, Careers, Interview
Teaching, Professor Jobs in India
GRE Prep and Free Courses