Postdoctoral Position in Biochemistry and Biophysics USA
Postdoctoral Position in Biochemistry and Biophysics (Galveston/USA)The hallmark of cancer biology is the uncontrolled growth of cells. This transformation relies on mutant cell signaling proteins such as Src, Raf-1, Erb, Her2, Bcr-Abl and others that are constitutively active and/or hyperactive leading to uncontrolled proliferation. In contrast to their normal counterparts, the activity of these mutant oncogenic proteins is highly dependent upon interaction with the molecular chaperone Hsp90. In normal cells, Hsp90 oversees the folding of client proteins. In cancer cells, Hsp90′s essential role is subverted to stabilize mutated oncogenic proteins resulting in neoplastic transformation. Hsp90 binds and hydrolyses ATP, an activity that is inhibited by the ansamycin antibiotic geldanamycin. Geldanamycin binds to the nucleotide binding pocket of Hsp90, displaces ATP and inhibits activation of numerous Hsp90 dependent oncogenic clients, making it an ideal candidate for broad spectrum cancer treatment. This project funded by TI-3D (Texas Initiati!
ve for Drug Discovery and Development) will focus on the characterization of newly designed synthetic derivatives of Geldanamycin, analyze their interaction with Hsp90 and test their potency to inhibit the Hsp90 dependent activation of oncogenes. For further information see our website: www.utmb.edu/ncb/Faculty/ObermannWolfgang.html
Requirements
The successful candidate will an expert in the generation of recombinant proteins and must be experienced in the analysis of protein-drug interactions by biophysical methods such as SPR (surface plasmon resonance) spectroscopy, fluorescence spectroscopy and ITC (isothermal calorimetry).
Please forward your application letter stating clearly how you pertain to the requirements for the position together with a curriculum vitae, a list of publications, and the names and contact information of three referees to wmoberma@utmb.edu
Contact:
Wolfgang M. J. Obermann, PhD, Associate Professor
Department of Neuroscience and Cell Biology
The University of Texas Medical Branch
Research Building 17, Rm. 5.212A
Galveston, TX 77555-0620
USA
Phone: ++1-409-747-1214
Email: wmoberma@utmb.edu
Scholarship Tags: Biochemistry, Biophysics, Position, Postdoctoral, USA
Scholarship Search
Important: Scholarship-Positions.com is not responsible for the content of any external websites linked to or referenced on this site.
Browse Scholarships
- Africa Scholarships
- Australia Scholarships
- Austria Scholarships
- Belgium Scholarships
- Canada Scholarships
- China Scholarships
- Denmark Scholarships
- France Scholarships
Recent USA Scholarships
Vanderbilt Postdoctoral Research at Vanderbilt University School of Medicine, 2012/13 USA 2012-2013 Fulbright NEXUS Regional Scholar Program, USA 2012 R G Menzies Scholarships for Australian Citizens, USA TLMI 4 Year College Degree Scholarship Program, USA 2012 2012-13 TLMI 2 Year College Degree Scholarship Program, USARecent UK Scholarships
RIBA Aedas Stephen Williams Scholarship in Architecture, 2012/13 RIBA Norman Foster Travelling Scholarship in Architecture, 2012 2012 Research Position in Pure Mathematics at University of Bristol, UK Postdoctoral Research Position in Synthesis and Analysis of Peptide-Based Porous Materials, UK Postdoctoral Research Position in Structural Engineering at University of Liverpool, UK 2012Recent Germany Scholarships
PhD Studentship in Polymer Sciences at German Institute for Polymers, Germany Postdoctoral/ PhD Student Postions in Genome Biology at GRK1721, 2012 Germany Bucerius PhD Scholarship in Migration Studies, 2012 Germany PhD Position in Theoretical Physics at Humboldt University Berlin, Germany Doctoral – Postdoctoral Program in Mathematics Education in Germany 2012Recent India Scholarships
2012 Summer Research Fellowships in Engineering at IIT Delhi, India The Ravi Sankaran Fellowship Program for Indian Students, 2012 Trinity College Dublin Scholarships for Postgraduate Students, Ireland 2012 2012 Henley Business School Scholarship India at University of Reading, UK POCE/POBE Scholarship Programme at Jawaharlal Nehru Centre for Advanced Scientific Research- Bangalore, IndiaWomen Scholarships
Call for Applications: Women Scientists Scheme (WOS-C) Training, India 2012 HHL Scholarship for Women in Business, Germany 2012 University Hall St Andrews Graduates’ Association (UHStAGA) Scholarship, UK 2012 International Fellowships Programme for Women in Japan WIA Foundation Annual 2012-2013 Scholarship for Women, USAAfrica Scholarships
Postdoctoral Research Fellowship in Geology for Australian Citizens in Tanzania, 2012 2nd Joint Call Research Proposal in Population, Reproductive Health and Economic Development, 2012 The 2012 TechWomen Professional Mentorship and Exchange Program, USA Internship Programme at African Development Bank, 2012 Africa MPhil / PhD Research Internships at PLASS Institute for Poverty, Land and Agrarian Studies, South AfricaScholarship Blog
Useful Links
Search in Worldwide UniversitiesOxford Laboratory Technology
Search Courses in Indian Universities
IndiaJobs.co.in, India Jobs Employment, Recruitment, Careers, Interview
Teaching, Professor Jobs in India
GRE Prep and Free Courses