Postdoctoral Research Scientist, NY, USA
Postdoctor al Research Scientist (Bronx (New York City), NY, USA)
My laboratory focuses on the pathogenesis of human mycoses, especially disease due to Candida parapsilosis, Histoplasma capsulatum, or Cryptococcus neoformans. I am seeking a highly motivated, creative candidate with a PhD, MD or DVM who has demonstrated an ability to work independently and a strong background in molecular and cell biology. My laboratory has been recognized as an enriching, interactive basic science environment. Please contact me if interested.
•Candida parapsilosis: This is the newest fungus to the laboratory. The incidence of C. parapsilosis infections has exploded in recent years and very little is known about its virulence. We developed the first efficient method for targeted gene deletion for C. parapsilosis and are actively pursuing targets to define what makes this fungus pathogenic. We are also targeting virulence associated genes in Candida albicans and studying their role in pathogenesis. Recent publication: Gácser, A, Trofa, D, Schäfer, W, Nosanchuk, JD. Targeted gene deletion in a clinical Candida parapsilosis isolate demonstrates the role of secreted lipase in virulence and pathogenesis. Journal of Clinical Investigation. 2007. 117(10):3049-58.
•Histoplasma capsulatum: Research on this fungus pertains to the development of active and passive immunotherapeutics. Since individuals with severe histoplasmosis [such as AIDS patients with disseminated disease] often lack effective cell-mediated immune responses, induction of an effective humoral response or passive administration of antibody has tremendous therapeutic potentials. My laboratory is the first to identify monoclonal antibodies that modify H. capsulatum infection. We are studying the mechanisms of antibody efficacy and are testing the recombinant antigens as a potential prophylactic and therapeutic vaccine. Also, we have embarked on studies testing the impact of co-stimulation on histoplasmosis and have demonstrated that the PD-1/PDL pathway is critically important to disease pathogenesis. Antibodies can interfere with this negative co-stimulation pathway and prevent lethal histoplasmosis. Recent publication: Lázár-Molnár, E, Gácser, A, Freedman, GJ, Al!
mo, SC, Nathenson, SG, Nosanchuk, JD. The PD-1/PD-L costimulatory pathway critically affects host resistance to the pathogenic fungus Histoplasma capsulatum. Proc Nat Acad Sci USA. 2008. 105(7):2658-2663
•Cryptococcus neoformans: We are primarily using this pathogen to elucidate the impact of melanin in pathogenic fungi. Melanin is a complex polymer of unknown structure that is prevalent throughout the biological kingdoms. Ongoing investigations are examining mechanisms of melanin synthesis and rearrangement by molecular, physical, and immunological methods. Recent publication: Dadachova, E, Bryan, RA, Howell, RC, Schweitzer, AD, Aisen, P, Nosanchuk, JD, Alfieri, A, Guha, C, Casadevall, A. Radioprotective properties of fungal melanin are a function of its chemical composition, free stable radical presence and spatial arrangement. PLoS ONE, 2007 May 23;2:e457.
Josh Nosanchuk, MD
nosanchu@aecom.yu.edu
Albert Einstein College of Medicine
Bronx (New York City), NY, USA
Ansprechpartner: nosanchu@aecom.yu.edu
Scholarship Tags: NY, Postdoctoral, research, Scientist, USA
Scholarship Search
Important: Scholarship-Positions.com is not responsible for the content of any external websites linked to or referenced on this site.
Browse Scholarships
- Africa Scholarships
- Australia Scholarships
- Austria Scholarships
- Belgium Scholarships
- Canada Scholarships
- China Scholarships
- Denmark Scholarships
- France Scholarships
Recent USA Scholarships
2012 The Charles Braver Language Exploration Grant at Russia, Kyrgyzstan, or Ukraine 2012 Development Fund for Black Students in Science and Technology, USA Boren Fellowships for U.S. Graduate to Study Abroad, 2013/14 2012 Jackson Hole Science Media International Awards, USA 2012 POMEPS TRE Grants in Political Science, USARecent UK Scholarships
RGU: Sport Scholarship at Robert Gordon University, UK 2012 Transform Together Scholarships for International Students, UK 2012 Sarmatian Bursary for Undergraduate at University College London, UK 2012 Architecture,Construction and Surveying Merit Scholarships at Robert Gordon University, UK 2012/13 2012 North American Merit Postgraduate Scholarship at Queen’s University Belfast, UKRecent Germany Scholarships
2012 PhD Thesis Position in Geomicrobiology at University of Tübingen, Germany PhD Position in Model Systems of Infectious Diseases at Leibniz Center Infection (LCI), 2012 Germany PhD Student in Quantitative Disease Proteomics at University of Freiburg, 2012 Germany PhD Studentship in Isotope Biogeochemistry at Helmholtz Centre for Environmental Research GmbH – UFZ, 2012 Germany 2012 PhD Position in System Ecotoxicology at Helmholtz Centre for Environmental Research – UFZ, GermanyRecent India Scholarships
3 PhD Position at PSG Institute of Advanced Studies, India 2012-2013 Trio World School Scholarships for High School Students, India 2012-2013 Meena Srinivasan Memorial Awards for Indian Artists, India 2012 Indo-Korean Joint Programme of Cooperation in Science and Technology, India 2012 Queen’s University Management School Postgraduate Scholarships for Indian Students, UKWomen Scholarships
UNESCO-L’OREAL International Fellowships Programme for Women in Life Sciences, 2013 Dulcie Bowman Scholarship for Hearing Impaired Women Students, New Zealand 2012 2013 Barbara Wood Memorial Foundation Scholarship, New Zealand and South Pacific The Eira Francis Davies Scholarship at Swansea University, 2012 UK Conchita Poncini Jimenez International Human Rights Fellowship at IFUW, 2012-2013Africa Scholarships
2012 TBA Masters Scholarship for African Citizens, Africa The Tropical Biology Association Small Grant, 2012 Africa 2012 Cranfield University MBA Scholarships, UK Postdoctoral Fellowship in Social Science at CODESRIA, 2012 Africa 2013 Research Partnership Ivorian-Switzerland Scholarship, AfricaScholarship Blog
Useful Links
Search in Worldwide UniversitiesOxford Laboratory Technology
Search Courses in Indian Universities
IndiaJobs.co.in, India Jobs Employment, Recruitment, Careers, Interview
Teaching, Professor Jobs in India
GRE Prep and Free Courses