Regulation of Sphingosine Kinases/Calcium Signalling by Sphingosine-1-phosphate
The lipid mediator, sphingosine-1-phosphate (S1P), regulates cell proliferation and migration, and is involved in processes such as angiogenesis, vascular contractility and permeability, lymphocyte trafficking, and inflammation. S1P is formed by sphingosine kinases and degraded by phosphatases and S1P lyase. The thesis projects are:
1. Regulation of activity and subcellular localization of sphingosine kinases. Aim is also to correlate the subcellular localization of S1P formation with a specific cell response, e.g., activation of S1P receptors.
2. Regulation of Ca2+ homeostasis by sphingosine kinases and S1P lyase. Knockout of these enzymes leads to perturbations of the cellular Ca2+ homeostasis. The underlying mechanisms and functional consequences have to be further analysed.
Methoden:
- Cell culture including primary cell culture
- Confocal microscopy / live cell imaging including Ca2+ imaging
- Diverse biochemical methods such as Western blot, sphingosine kinase assays etc.
Anfangsdatum: 28. Mai 2008
geschätzte Dauer: 3 years
Bezahlung: BAT IIa/2
Veröffentlichungen:
Alemany et al. (2007) Naunyn-Schmiedeberg´s Arch Pharmacol 374:413-428;
Meyer zu Heringdorf und Jakobs (2007) Biochim Biophys Acta 1768:923-940;
Lichte et al. (2008) J Invest Dermatol 128:1487-1498.
Homepage: http://www.kgu.de/zpharm/allg
Fachgebiete: Biologie Chemie Pharmazie
Thema: Doktorarbeit: Regulation of sphingosine kinases / Calcium signalling by sphingosine-1-phosphate
Ansprechpartner: Prof. Dagmar Meyer zu Heringdorf
Antwort an: heringdorf@med.uni-frankfurt
Institution: Institut für Allgemeine Pharmakologie und Toxikologie
Ort: 60590 Frankfurt am Main, Theodor-Stern-Kai 7
Scholarship Tags: Calcium Signalling, Kinases, PhD, Regulation, Sphingosine, Sphingosine-1-phosphate
Scholarship Search
Important: Scholarship-Positions.com is not responsible for the content of any external websites linked to or referenced on this site.
Browse Scholarships
- Africa Scholarships
- Australia Scholarships
- Austria Scholarships
- Belgium Scholarships
- Canada Scholarships
- China Scholarships
- Denmark Scholarships
- France Scholarships
Recent USA Scholarships
The AIA Society Outreach Grant Program at Archaeological Institute of America, 2012 USA The Archaeology of Portugal Fellowship for International Students at AIA, 2012 USA 2013 Teaching Excellence and Achievement Program, USA International Leaders in Education Program for Indian Teachers, 2013 USA 2012-2013 Kathern F. Gruber Scholarship and Thomas H. Miller Awards, USARecent UK Scholarships
Kingston University Undergraduate International Scholarships, 2012 UK Overseas Research Scholarship (ORS) for Non-EU Applicants at University of York, 2012 UK Scholarship for Overseas Students (SOS) at University of York, 2012 UK Kingston University International Postgraduate Scholarships, 2012 UK 2012 Donner Scholarship at University of Cambridge, UKRecent Germany Scholarships
CGS Interantional Scholarships for Doctoral Program at University of Cologne, 2012 Germany Max F. Perutz International PhD Programme in Chromosome Dynamics, 2012 Germany PhD Positions in NanoBioTechnology at Center for NanoScience LMU, 2012 Germany PhD in Life Sciences at The International Giessen Graduate School for the Life Sciences, Germany Germany Postgraduate Training Program – 2012 Cycle (PhD studies in Germany)Recent India Scholarships
Kingston University Postgraduate Scholarships for Indian Students, 2012 UK 2013 Teaching Excellence and Achievement Program, USA Fulbright Foreign Language Teaching Assistant Program for Indian, 2013 USA 2013 Fulbright-Nehru Senior Research Fellowships for Indians, USA 2013-2014 Fulbright Teacher Exchange Program for US and Indian Students, USA and IndiaWomen Scholarships
Sloan MSc Women’s Scholarship at London Business School, 2013 UK 2012-2013The Saint Paul College Club, Inc. AAUW Undergraduate Scholarship, USA 2012 L’Oréal Canada for Women in Science Research Excellence Fellowships, Canada 2012 Gertrude M. Cox Scholarship at American Statistical Association to Study in USA, Canada 2012 Women in Games Scholarship at Vancouver Film School, CanadaAfrica Scholarships
2012-2013 South Africa Investec Scholarship for MBA Students, UK 2012-2013 Mandela Magdalene College Scholarship for South Africa, UK 2012 Call for Proposals: Grant Awards for Global Environmental Change Research, Africa CARTA Call for Applications for PhD Fellowships 2012-2013, Africa Africa Biosciences Challenge Fund Research Fellowship, 2012 AfricaScholarship Blog
Useful Links
Search in Worldwide UniversitiesOxford Laboratory Technology
Search Courses in Indian Universities
IndiaJobs.co.in, India Jobs Employment, Recruitment, Careers, Interview
Teaching, Professor Jobs in India
GRE Prep and Free Courses