SULSA Prize PhD Studentship in Systems Biology
A PhD student position is available in the
laboratory of V Anne Smith at the University of
St Andrews. Please visit
http://biology.st-andrews.ac.uk/vannesmithlab/
for more information on the lab, and feel free to
contact me at anne.smith@st-andrews.ac.uk with
questions.
A pdf of the below PhD advertisement is downloadable from:
http://biology.st-andrews.ac.uk/vannesmithlab/SULSA2008.pdf
SULSA Prize PhD Studentship in Systems Biology
Gene and protein networks related to breast cancer
Systems biology is a growing area, combining
modelling and computational analysis with
biological experimentation. It enables us to
understand biological processes on a broad-scale
like never before: for example, instead of
analysing a gene or its protein in isolation, we
now analyse entire networks. Such systems level
understanding impacts research in multiple areas,
including cancer biology.
In this studentship, you will examine gene and
protein regulatory networks related to breast
cancer. You will both build computational models
and perform biological experiments. The project
will lever two systems biology methods-dynamical
systems modelling (DSM) of large cellular
networks and Bayesian network (BN) inference of
network structure-to produce data-driven models
of gene and protein regulation networks relevant
to breast cancer. DSM handles well the sparsity
of data; however, networks are manually described
and uniqueness is difficult to verify. BNs
complement this by recovering network structure
de novo from data and predicting several
alternative structures; however, they have high
data demands. You will use these two
complementary methods to suggest structures
consistent with the data and to identify the key
experiments required to discriminate between
alternative solutions.
You will be based at St Andrews University and
jointly supervised by Dr V Anne Smith (St
Andrews), Prof John W Crawford (Abertay), and
Prof David J Harrison (Edinburgh). Dr Smith will
provide expertise on BNs; Prof Crawford and Prof
Harrsion will provide expertise on DSM and
biological experimentation respectively. As a
SULSA Student, you will also have the opportunity
to engage in the SULSA (Scottish Universities
Life Science Alliance) community across Scotland,
including meetings with other SULSA Students. For
more details, please contact
anne.smith@st-andrews.ac.uk and/or visit:
http://biology.st-andrews.ac.uk/vannesmithlab/
Funding by SULSA plus St Andrews Biology: stipend and fees covered to EU level
Scholarship Tags: Biology, PhD, Prize, Studentship, SULSA, Systems
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