Looking for a motivated PhD to join our team to study mechanisms of cancer cell invasion into 3D matrices. We are particularly interested in the role of formins and their impact on cytoskeletal dynamics for cell morphology and motility. A focus of the lab is the signal regulation of formins in actin dynamics as well as for transcriptional regulation and the tight interplay between actin-regulated transcription and bleb-associated cancer cell invasion. Interested applicants should send a CV along with two references and an outline why or how they got interested in this topic to [email protected].
For more information please see
Faix J. and Grosse R. 2006. Staying in shape with formins. Dev. Cell 10: 693-706.
Grosse R., Copeland J.W., Newsome T., Way M. and Treisman R. 2003. A role for VASP in Rho-Diaphanous signalling to actin dynamics and SRF activity. EMBO J. 22: 3050-3061.
Brandt D.T., Marion, S., Griffiths G., Watanabe T., Kaibuchi K. and Grosse R. 2007. Dia1 and IQGAP1 interact in cell migration and phagocytic cup formation. J. Cell Biol. 177, in press
Kitzing T.M., Sahadevan A, Brandt, D.T., Knieling H., Hannemann S., Fackler O.T., Gro?hans J. and Grosse R. 2007. Positive feedback between Dia1, LARG and RhoA regulates cell morphology and invasion. Genes Dev. 21:1478-1483.
Pharmakologisches Institut, University of Heidelberg