Fellowship at University of Amsterdam
Study Subject: Vibrational Spectroscopy
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Employer: University of Amsterdam
Fellowship Description: Within the Molecular Photonics Group a project sponsored by an ERC Starting Grant is carried out, aiming to develop and apply time-resolved vibrational spectroscopic methods for investigating protein folding.
Protein folding, the process by which a protein assumes its three-dimensional shape, is one of the basic unsolved problems of biophysical research. Many of the structural changes taking place during protein folding, especially during the early stages, are as yet poorly understood. In this research project, time-resolved vibrational spectroscopy will be used to study protein folding. We will trigger the folding, for instance by a temperature jump, and track the folding process in real time using one- and two-dimensional vibrational spectroscopy in combination with site-specific labeling. This will make it possible to obtain a structurally and temporally resolved picture of protein folding, which can be regarded as a ‘molecular movie’ of the folding process.
The candidate should have a relevant PhD degree and experience in time-resolved (preferably vibrational) spectroscopy and nonlinear optics
Appointment is for a period of 12 months. The salary will be in accordance with the University regulations for academic personnel, and will range from €2,379 to €3,755 (salary scale 10) gross per month, based on a full-time employment and depending on expertise and previous experience. The Collective Employment Agreement of the Dutch Universities is applicable.
Fellowship Application Deadline: 30 November 2010
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