Applications are invited for a 3 years PhD studentship starting in October 2014 at University of Cambridge. EEA applicants are eligible for this PhD studentship. Applicants must attain a first or upper second class degree (or equivalent) in pharmacology or a relevant biological subject. This studentship includes stipend and College/University fees at the Home/EU rate only. Application deadline is 31 January 2014.
Study Subject (s): Studentship is awarded in Platelet Pharmacology at University of Cambridge in UK.
Course Level: Studentship is available for pursuing PhD degree at University of Cambridge in UK.
Scholarship Provider: British Heart Foundation
The award can be taken at: UK
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Eligibility:-Candidates must attain a first or upper second class degree (or equivalent) in pharmacology or a relevant biological subject.
-An interest in cardiovascular pharmacology is desirable.
-Candidates should normally be a national of the EEA (European Economic Area) with relevant connection to the EEA.
-Relevant connection would be established if an individual has (i) been ordinarily resident in the EEA and (ii) has an appropriate degree from a university in the EEA or has worked in a university, hospital or research institution in the EEA for at least the past three years or did so before taking up an appointment outside the EEA.
-Candidates who are not EEA nationals may be eligible to apply if the individual has worked in a university (providing it is not for the sole purpose of full-time education), hospital or research institution in the UK for at least three years, prior to the date of application.
Scholarship Open for Students of Following Countries: Citizens of the EEA (European Economic Area) countries: Iceland, Norway, Finland, Sweden, Ireland, United Kingdom, Denmark, Germany, Netherlands, Belgium, Luxembourg, Austria, Portugal, Spain, France, Italy, Greece, Liechtenstein, Czech Republic, Estonia, Cyprus, Latvia, Lithuania, Hungary, Malta, Poland, Slovenia, Slovakia, Bulgaria, Romania are eligible for this PhD studentship. Non EEA nationals may be eligible to apply if the individual has worked in a university (providing it is not for the sole purpose of full-time education), hospital or research institution in the UK for at least three years, prior to the date of application.
Description: Selective serotonin reuptake inhibitors (SSRIs), which are widely used as anti-depressants, block transport of serotonin into nerve terminals and platelets. Clinical evidence suggests that SSRIs have effects on haemostasis and thrombosis and platelet function. However, these effects are poorly understood and, since few relevant in vitro studies have been conducted, the mechanisms by which SSRIs modify platelet function remains unclear. One study has suggested that citalopram, a commonly used SSRI, selectively inhibits collagen-induced platelet activation1, although the mechanistic basis for the selectivity is unknown. The project will characterize and investigate the mechanism of platelet inhibition by SSRIs. Platelet function will be measured using diverse methodologies and quantitative pharmacological designs. Advanced statistical and modeling techniques will be used to analyze the data. The study will enhance our understanding of basic platelet biology and pharmacology and provide an improved mechanistic basis for understanding the effect of SSRI treatment on haemostasis and thrombosis. The successful candidate will receive a diverse and detailed scientific training in platelet physiology and pharmacology.
Number of award(s): Not Known
Duration of award(s): The funds for this post will be available for 3 years in the first instance.
What does it cover? The stipend will be at current BHF rates (Year 1 – £19,919; Year 2 – £20,915; and Year 3 – £21,960) and College/University fees are included but at the Home/EU rate only. A travel fund of £1,000 is also available for the student to present at or attend scientific meetings relevant to the grant.
Selection Criteria: Not Known
Notification: Interviews will be held during February 2014.
How to Apply: To apply please e-mail a covering letter together with your CV and contact details for two academic referees to gej1000-at-cam.ac.uk. Please add ‘BHF Studentship’ to the subject line of your e-mail.
application Deadline: The deadline for applications is 31 January 2014.